Easy Best Stuffing Meatloaf

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I’ve made countless versions of meatloaf over the years, but this Easy Best Stuffing Meatloaf might be my favorite yet. It combines everything I love about classic comfort food: tender, juicy beef, a savory base, and a rich ketchup glaze on top. What really sets this version apart is the use of stuffing mix—it adds the perfect blend of herbs and moisture, and saves me from chopping onions and mixing in a dozen other things. It’s fast, flavorful, and perfect for busy weeknights or when I just want something satisfying without the fuss.

The first time I tested this meatloaf with stuffing mix, I was amazed at how much it simplified the process. No breadcrumbs, no milk, no extra seasoning blends—just one shortcut ingredient that does all the heavy lifting. This recipe is a winner not only because it tastes incredible, but because it cuts down prep time and cleanup. It’s cozy, hearty, and gives you all the nostalgic feels of a Sunday dinner with half the effort.

Why You’ll Love This Easy Best Stuffing Meatloaf

• It uses boxed stuffing mix, which packs in seasoning and texture in one step.
• There’s minimal prep—no sautéing onions or mixing complicated ingredients.
• The glaze is tangy, sweet, and caramelizes perfectly in the oven.
• It’s freezer-friendly and great for leftovers.
• Ideal for quick family dinners or make-ahead meal prep.

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What Kind of Stuffing Mix Should I Use?

You can use any traditional boxed stuffing mix, but I prefer the herb-seasoned variety for the best flavor payoff. You can go with Stove Top, Pepperidge Farm, or even a generic brand. Just make sure it’s the dry kind and not already cooked. If you want a little extra punch, try using cornbread stuffing or a mix with garlic and herbs for added depth.

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Options for Substitutions

Don’t have stuffing mix? You can still make this meatloaf by using crushed seasoned croutons or even breadcrumbs with Italian seasoning. For a gluten-free version, opt for a gluten-free stuffing mix or use crushed rice crackers with herbs. Ground turkey or chicken can replace the beef if you’re looking for a leaner option, and a touch of barbecue sauce in place of ketchup will give it a smoky twist. You can even sneak in some shredded veggies like zucchini or carrots for a nutritious boost.

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Ingredients for this Easy Best Stuffing Meatloaf

Ground beef – This is the foundation of the meatloaf. I prefer using 80/20 beef for a balance of moisture and flavor.

Boxed stuffing mix – The game-changer! It adds seasoning and structure to the meatloaf without extra effort. Herb-seasoned stuffing works best.

Eggs – Act as a binder to help the loaf hold its shape while staying tender.

Water – Softens the stuffing mix just enough to blend well with the meat.

Ketchup – Used both inside the mixture for moisture and on top as a sweet-savory glaze.

Worcestershire sauce – Adds a deep umami flavor that enhances the meatiness.

Garlic powder – A simple but impactful seasoning that rounds out the flavor.

Parsley (optional for garnish) – Adds a pop of freshness and color to the finished dish.

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Step 1: Preheat and Prepare

Preheat your oven to 350°F (175°C). Line a loaf pan with parchment paper or lightly grease it to prevent sticking. This helps with cleanup later and makes lifting the loaf easier.

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Step 2: Mix the Ingredients

In a large mixing bowl, combine the ground beef, dry stuffing mix, eggs, water, 1/4 cup of ketchup, Worcestershire sauce, and garlic powder. Use your hands or a large spoon to gently combine everything. Be careful not to overmix or the meatloaf could become tough.

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Step 3: Form the Loaf

Transfer the mixture into your prepared loaf pan. Press it in gently, shaping it evenly from edge to edge so it cooks uniformly. Smooth the top for an even glaze layer.

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Step 4: Add the Glaze

Spread the remaining 1/4 cup of ketchup evenly over the top of the loaf. This will caramelize in the oven and create that delicious, tangy-sweet crust everyone loves.

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Step 5: Bake the Meatloaf

Bake uncovered for about 55-60 minutes, or until the internal temperature reaches 160°F (71°C). If you notice the glaze browning too quickly, you can tent it with foil halfway through.

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Step 6: Rest and Slice

Let the meatloaf rest in the pan for 10 minutes after baking. This allows the juices to redistribute and makes slicing much easier. Garnish with chopped parsley before serving if desired.

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How Long to Prepare the Easy Best Stuffing Meatloaf

Prep Time: The preparation takes about 10–15 minutes. Since the stuffing mix replaces several ingredients (like breadcrumbs and seasonings), there’s less chopping and measuring involved. You’ll spend most of the time mixing ingredients and shaping the loaf.

Cooking Time: Baking takes approximately 55–60 minutes at 350°F (175°C). Add an extra 10 minutes for resting once it comes out of the oven. Altogether, the full process from start to plate takes around 1 hour and 15 minutes.

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Tips for Perfect Stuffing Meatloaf

• Don’t overmix: Use a gentle hand when combining ingredients to avoid a dense loaf.
• Check the internal temp: A thermometer reading of 160°F ensures it’s fully cooked without drying out.
• Rest before slicing: Letting it sit for 10 minutes after baking helps lock in moisture and makes slicing neater.
• Use parchment paper: This makes lifting the meatloaf out of the pan super easy and keeps the bottom from sticking.
• Add a second glaze layer: Midway through baking, brush on another layer of ketchup for extra flavor.

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Watch Out for These Mistakes While Cooking

• Using lean beef: Meat that’s too lean can lead to a dry loaf. Stick with 80/20 ground beef for best results.
• Skipping the rest time: Cutting too early causes juices to run out, making it dry.
• Not soaking the stuffing mix: If you skip the water step, the dry stuffing won’t blend well and may leave crunchy bits.
• Uneven loaf shape: A lopsided loaf won’t cook evenly—press it gently but uniformly into the pan.
• Overbaking: Going past 160°F can lead to a crumbly or dry texture. Always check the temp with a meat thermometer.

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What to Serve With Easy Best Stuffing Meatloaf?

1. Creamy Mashed Potatoes

You can’t go wrong with this classic pairing. The rich potatoes complement the savory meatloaf perfectly.

2. Roasted Green Beans

They add freshness and a crunchy texture that balances the soft meatloaf.

3. Buttered Corn

Sweet corn brings a little pop of sweetness and color to your plate.

4. Macaroni and Cheese

For a total comfort food feast, mac and cheese is always welcome.

5. Garden Salad with Vinaigrette

If you want to keep it light, serve a simple side salad to add contrast and crispness.

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Storage Instructions

Refrigerator: Store leftover meatloaf in an airtight container or wrapped tightly with foil or plastic wrap. It will keep in the fridge for up to 4 days.

Freezer: To freeze, wrap individual slices or the whole loaf in plastic wrap, then foil. Store in a freezer-safe bag or container for up to 3 months. Thaw overnight in the fridge before reheating.

Reheating: Warm slices in the oven at 300°F, covered with foil, for about 15–20 minutes, or microwave in short bursts until heated through.

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Estimated Nutrition (Per Serving)

• Calories: ~340
• Protein: 22g
• Carbohydrates: 18g
• Fat: 20g
• Saturated Fat: 8g
• Cholesterol: 110mg
• Sodium: 680mg
• Fiber: 1g
• Sugar: 4g

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Frequently Asked Questions

How do I keep meatloaf from falling apart?

Make sure to include enough binder (like eggs and stuffing mix), and let it rest after baking so it sets properly.

Can I use ground turkey instead of beef?

Yes, you can substitute ground turkey for a leaner version, but add a bit of olive oil or an extra egg to keep it moist.

Is the stuffing mix already cooked?

No, you use it dry straight from the box. It will soften as it absorbs the moisture from the eggs and water.

Can I make this ahead of time?

Absolutely! You can prepare the mixture and store it in the fridge for up to 24 hours before baking.

What’s the best way to reheat leftovers?

Reheat in the oven at 300°F covered with foil, or in the microwave for 1–2 minutes per slice until heated through.

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Conclusion

Easy Best Stuffing Meatloaf is the shortcut comfort food recipe I keep coming back to when I need something hearty, nostalgic, and quick. The stuffing mix adds herby richness and saves tons of time, and the ketchup glaze delivers that sweet-savory finish we all crave. Whether you’re feeding a family or batch-cooking for the week, this meatloaf delivers every time with minimal effort and maximum flavor.

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